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Getting invasive with GEP100 and Arf6

Nature Cell Biology volume 10, pages 1618 (2008) | Download Citation

When cancers spread, they detach from their neighbouring cells and invade the surrounding tissues to reach blood or lymphatic vessels. EGF receptors induce cancer invasion by directly activating GEP100, one of several potential activators of the GTP-binding protein Arf6.

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Author information

Affiliations

  1. Ferran Valderrama and Anne J. Ridley are at the Randall Division of Cell and Molecular Biophysics, New Hunts House, Guy's Campus, King's College London, SE1 1UL, UK.  anne.ridley@kcl.ac.uk

    • Ferran Valderrama
    •  & Anne J. Ridley

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DOI

https://doi.org/10.1038/ncb0108-16

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