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Getting invasive with GEP100 and Arf6

Nature Cell Biology volume 10, pages 16–18 (2008)Cite this article

When cancers spread, they detach from their neighbouring cells and invade the surrounding tissues to reach blood or lymphatic vessels. EGF receptors induce cancer invasion by directly activating GEP100, one of several potential activators of the GTP-binding protein Arf6.

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Figure 1: Schematic model of the potential mechanisms for EGFR/GEP100/Arf6-induced invasion of epithelial cancers.

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Authors and Affiliations

  1. Ferran Valderrama and Anne J. Ridley are at the Randall Division of Cell and Molecular Biophysics, New Hunts House, Guy's Campus, King's College London, SE1 1UL, UK. anne.ridley@kcl.ac.uk,

    Ferran Valderrama & Anne J. Ridley

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  1. Ferran Valderrama
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Valderrama, F., Ridley, A. Getting invasive with GEP100 and Arf6. Nat Cell Biol 10, 16–18 (2008). https://doi.org/10.1038/ncb0108-16

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