Telomeres on the Cdk roller-coaster ride

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Each round of DNA replication results in the erosion of telomeres, the ends of linear chromosomes. Telomerase counteracts telomere shortening by synthesizing new DNA sequences in a time period restricted to late S a d G2 cell-cycle phases, even though the enzyme is active throughout the cell cycle. A recent study directly implicates cyclin dependent kinase (Cdk1) in the regulation of telomere elongation during the cell cycle.

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Figure 1: Telomere elongation follows the cycles of activation of Cdk1.

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