Leading-edge research: PtdIns(3,4,5)P3 and directed migration

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New studies reveal the dynamic accumulation of phosphatidylinositol (3,4,5) trisphosphate (PtdIns(3,4,5)P3) at the leading edge of primary neutrophils during chemotaxis. They also demonstrate that SHIP1, rather than phosphatase and tensin homologue (PTEN), is responsible for the degradation and localization of this lipid in neutrophils and shed light on the role of PtdIns(3,4,5)P3 in directional sensing.

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Figure 1: The effect of PtdIns(3, 4, 5)P3 levels on chemotaxis.
Figure 2: Schematic representation of a model for directional sensing.

References

  1. 1

    Weiner, O. Curr. Opin. Cell Biol. 14, 196–202 (2002).

  2. 2

    Franca-Koh, J., Kamimura, Y. & Deveotes, P.N. Curr. Opin. Genet. Dev. 16, 333–338 (2006).

  3. 3

    Meili, R. et al. EMBO J. 18, 2092–2105 (1999).

  4. 4

    Servant, G. et al. Science 287, 1037–1040 (2000).

  5. 5

    Parent, C.A. & Devreotes, P.N. Science 284, 765–770 (1999).

  6. 6

    Funamoto, S., Meili, R., Lee, S., Parry, L. & Firtel, R.A. Cell 109, 611–623 (2002).

  7. 7

    Iijima, M. & Devreotes, P.N. Cell 109, 599–610 (2002).

  8. 8

    Ward, S.G. Trends Immunol. 27, 80–87 (2006).

  9. 9

    Nishio, M. et al. Nature Cell Biol. 9, 36–44 (2007).

  10. 10

    Ferguson, G.J. et al. Nature Cell Biol. 9, 86–91 (2007).

  11. 11

    Helgason, C.D. et al. Genes Dev. 12, 1610–1620 (1998).

  12. 12

    Liu, Q. et al. Genes Dev. 13, 786–791 (1999).

  13. 13

    Van Keymeulen, A. et al. J. Cell Biol. 174, 437–445 (2006).

  14. 14

    Chen, L. et al. Mol. Biol. Cell. 14, 5028–5037 (2003).

  15. 15

    Hannigan, M. et al. Proc. Natl Acad. Sci. USA 99, 3603–3608 (2002).

  16. 16

    Loovers, H.M. et al. Mol. Biol. Cell 17, 1503–1513 (2006).

  17. 17

    Sasaki, A.T., Chun, C., Lee, S., Takeda, K. & Firtel, R.A. J. Cell Biol. 167, 505–518 (2004).

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