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Chromatin and DNA repair: the benefits of relaxation

DNA is tightly wrapped around histones to form chromatin. How DNA repair molecules interact with this chromatin structure is an emerging question. New findings suggest that chromatin structure impedes the access of DNA repair proteins to sites of DNA damage, thus establishing a mechanism for the function of chromatin remodelling complexes during DNA repair.

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Figure 1: Chromatin-dependent and -independent responses to DNA damage.

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Downey, M., Durocher, D. Chromatin and DNA repair: the benefits of relaxation. Nat Cell Biol 8, 9–10 (2006). https://doi.org/10.1038/ncb0106-9

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