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Ephrins make eyes with planar cell polarity

Interactions between Eph receptors and ephrins can restrict or enable the movement of cells by promoting cell repulsion or invasion. Ephrins have now been shown to regulate cell migration by interacting with the planar cell polarity (PCP) pathway.

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Figure 1: Relationships between the canonical Wnt pathway, planar cell polarity (PCP) pathway and ephrinB1.

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Poliakov, A., Wilkinson, D. Ephrins make eyes with planar cell polarity. Nat Cell Biol 8, 7–8 (2006). https://doi.org/10.1038/ncb0106-7

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