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Nuclear pore complexes: Round the bend?

Nature Cell Biology volume 7, pages 10–12 (2005)Cite this article

Nuclear pore complexes intuitively seem functionally analogous to transmembrane channels. Recent bioinformatic analysis, however, suggests a quite different evolutionary relationship: one between nuclear pore complexes and vesicle coat components. This has led to the provocative hypothesis that these distinct structures share a common role in bending membranes.

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Figure 1: Vesicles and nuclear pores have different surface topologies.
Figure 2: Proposed structural homology between vesicle coats and components of the yNup84 complex.

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  1. the European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, 69117, Germany

    Wolfram Antonin & Iain W. Mattaj

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  1. Wolfram Antonin
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  2. Iain W. Mattaj
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Antonin, W., Mattaj, I. Nuclear pore complexes: Round the bend?. Nat Cell Biol 7, 10–12 (2005). https://doi.org/10.1038/ncb0105-10

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