Traditional mammalian gene knockout experiments identify the first critical requirement for a gene product during development. Unfortunately, they often lead to primary lethality, providing very little information as to gene function. In this issue, Sam Driver and colleagues have developed a transient, antisense-based strategy to inhibit gene function in utero, permitting the stage-specific analysis of gene function and identification of secondary phenotypes (pp. 1184; Research News p.1158).
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Frederickson, R. Antisense scores a knockout. Nat Biotechnol 17, 1150 (1999). https://doi.org/10.1038/70674
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DOI: https://doi.org/10.1038/70674