Stability Properties of Photopolymerized Liposomes

Abstract

Lipid vesicles (liposomes) can be formed from [1,2–(methacryloyloxy)dodecanoyl]–L–α–phosphatidylcholine, a photopolymerizable analog of phosphatidylcholine. As compared to conventional liposomes, the photopolymerized vesicles display enhanced mechanical stability and enhanced retention of lipophilic compounds. Thus, while detergents solubilize conventional vesicles and release incorporated lipophilic markers such as cholesterol oleate, the photopolymerized vesicles retain lipophilic compounds even at extremely high detergent concentrations. Photopolymerized vesicles may prove to be useful in certain aspects of the formulation and controlled delivery of hydrophilic and lipophilic drugs.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Papahadjopoulos, D. (ed.) 1978. Liposomes in Biology and Medicine. Ann. N. Y. Acad. Sci., Vol. 308.

  2. 2

    Juliano, R.L. and Layton, D. 1980. Liposomes as a drug delivery system, p. 189–236. In: Drug Delivery Systems: Characteristics and Biomedical Applications. R. Juliano (ed.), Oxford University Press, New York.

  3. 3

    Wilson, T. and Cave, L. 1983. New commercial opportunities for liposomes emerge. BIO/TECHNOLOGY 1: 148–154.

  4. 4

    Fendler, J.H. 1982. Membrane Mimetic Systems. J. Wiley Interscience, New York.

  5. 5

    Regen, S.L., Singh, A., Oehme, G. and Singh, M. 1982. Polymerized phosphatidylcholine vesicles. Synthesis and characterization. J. Am. Chem. Soc. 104: 791–795.

  6. 6

    Hub, H.H., Hopfer, B., Koch, H. and Ringsdorf, H. 1980. Polymerizable phospholipid analogs—new stable biomembrane and cell models. Angew. Chem. 19: 938–940.

  7. 7

    Johnston, D.X., Sanghera, S., Pons, M. and Chapman, D. 1980. Phospholipid polymers—synthesis and spectral characterization. Biochim. Biophys. Acta 602: 57–69.

  8. 8

    O'Brien, D.F., Whitesides, T.H. and Klingbiel, R.T. 1981. The photopolymerization of lipid diacetylenes in biomolecular—layer membranes. J. Polymer Sci., Polymer Lett. 19: 95–101.

  9. 9

    Tundo, P., Kippenberger, D.J., Klahn, P.L., Prieto, N.E., Jao, T. and Fendler, J.H. 1982. Functionally polymerized surfactant vesicles: synthesis and characterization. J. Am. Chem. Soc. 104: 456–461.

  10. 10

    Fildes, F.J.T. 1981. Liposomes: The industrial viewpoint, p. 465–485. In: Liposomes: From Physical Structure to Therapeutic Applications, C. G. Knight (ed.), Elsevier-North Holland, Amsterdam.

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Juliano, R., Regen, S., Singh, M. et al. Stability Properties of Photopolymerized Liposomes. Nat Biotechnol 1, 882–885 (1983). https://doi.org/10.1038/nbt1283-882

Download citation

Further reading