Stability Properties of Photopolymerized Liposomes


Lipid vesicles (liposomes) can be formed from [1,2–(methacryloyloxy)dodecanoyl]–L–α–phosphatidylcholine, a photopolymerizable analog of phosphatidylcholine. As compared to conventional liposomes, the photopolymerized vesicles display enhanced mechanical stability and enhanced retention of lipophilic compounds. Thus, while detergents solubilize conventional vesicles and release incorporated lipophilic markers such as cholesterol oleate, the photopolymerized vesicles retain lipophilic compounds even at extremely high detergent concentrations. Photopolymerized vesicles may prove to be useful in certain aspects of the formulation and controlled delivery of hydrophilic and lipophilic drugs.

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Juliano, R., Regen, S., Singh, M. et al. Stability Properties of Photopolymerized Liposomes. Nat Biotechnol 1, 882–885 (1983).

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