Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

MicroRNAs fine-tune oncolytic viruses

Nature Biotechnology volume 26, pages 1346–1348 (2008)Cite this article

Targeting by tissue-specific microRNAs enhances the efficacy and safety of tumor-killing viruses.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Control of transgene expression by tissue-specific miRNAs.

Katie Ris-Vicari

References

  1. Brown, B.D. et al. Nat. Med. 12, 585–591 (2006).

    Article  CAS  Google Scholar 

  2. Brown, B.D. et al. Nat. Biotechnol. 25, 1457–1467 (2007).

    Article  CAS  Google Scholar 

  3. Edge, R.E. et al. Mol. Ther. 16, 1437–1443 (2008).

    Article  CAS  Google Scholar 

  4. Ylösmäki, E. et al. J. Virol. 82, 11009–11015 (2008).

    Article  Google Scholar 

  5. Kelly, E.J., Hadac, E.M., Greiner, S. & Russell, S.J. Nat. Med. 14, 1278–1283 (2008).

    Article  CAS  Google Scholar 

  6. Ivanovska, I. & Cleary, M.A. Cell Cycle 7, 3137–3142 (2008).

    Article  CAS  Google Scholar 

  7. Zeng, Y., Yi, R. & Cullen, B.R. Proc. Natl. Acad. Sci. USA 100, 9779–9784 (2003).

    Article  CAS  Google Scholar 

  8. Xu, S. et al. J. Biol. Chem. 282, 25053–25066 (2007).

    Article  CAS  Google Scholar 

  9. Obbard, D.J., Gordon, K.H., Buck, A.H. & Jiggins, F.M. Philos. Trans. R. Soc. Lond. B Biol. Sci. 364, 99–115 (2009).

    Article  CAS  Google Scholar 

  10. Parato, K.A., Senger, D., Forsyth, P.A. & Bell, J.C. Nat. Rev. Cancer 5, 965–976 (2005).

    Article  CAS  Google Scholar 

  11. Liu, T.C., Galanis, E. & Kirn, D. Nat. Clin. Pract. Oncol. 4, 101–117 (2007).

    Article  CAS  Google Scholar 

  12. Berry, L.J., Au, G.G., Barry, R.D. & Shafren, D.R. Prostate 68, 577–587 (2008).

    Article  Google Scholar 

  13. Dekel, B. et al. Acta Paediatr. 91, 357–359 (2002).

    Article  CAS  Google Scholar 

  14. Deng, S. et al. Cell Cycle 7, 2643–2646 (2008).

    Article  CAS  Google Scholar 

  15. He, L., He, X., Lowe, S.W. & Hannon, G.J. Nat. Rev. Cancer 7, 819–822 (2007).

    Article  CAS  Google Scholar 

  16. Barnes, D. et al. Cell Host Microbe 4, 239–248 (2008).

    Article  CAS  Google Scholar 

  17. Kong, W., Zhao, J.J., He, L. & Cheng, J.Q. J. Cell. Physiol. 218, 22–25 (2008).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. John C. Bell is in the Ottawa Health Research Institute, Ottawa, Ontario K1G 0K8, Canada jbell@ohri.ca,

    John C Bell

  2. David Kirn is at Jennerex Inc., One Market St., Spear Tower, Suite 2260, San Francisco, California 94105, USA. dkirn@jennerex.com,

    David Kirn

Authors
  1. John C Bell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David Kirn
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

J.C.B. is scientific officer of Jennerex, Inc., a company developing oncolytic virus therapeutics.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bell, J., Kirn, D. MicroRNAs fine-tune oncolytic viruses. Nat Biotechnol 26, 1346–1348 (2008). https://doi.org/10.1038/nbt1208-1346

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt1208-1346

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing