The properties of the different IgG isotypes should be considered in developing therapeutic antibodies.
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References
van der Neut Kolfschoten, M. et al. Science 317, 1554–1557 (2007).
Jefferis, R. Expert Opin. Biol. Ther. 7, 1401–1413 (2007).
Carter, P. Nat. Rev. Immunol. 6, 343–357 (2006).
Filpula, D. Biomol. Eng. 24, 201–215 (2007).
van der Zee, J.S. et al. J. Immunol. 137, 3566–3571 (1986).
Schuurman, J. et al. Immunology 97, 693–698 (1999).
Angal, S. Mol. Immunol. 30, 105–108 (1993).
Schuurman, J. et al. Mol. Immunol. 38, 1–8 (2001).
Aalberse, R.C. & Schuurman, J. Immunology 105, 9–19 (2002).
Forrer, K. et al. Anal. Biochem. 334, 81–88 (2004).
Taylor, F.R. et al. Anal. Biochem. 353, 204–208 (2006).
Yoo, E.M. et al. J. Immunol. 170, 3134–3138 (2003).
Lewis, M.J. Mol. Immunol. 45, 818–827 (2007).
Duncan, A. et al. Nature 332, 563–564 (1988).
Suitters, A.J. et al. J. Exp. Med. 179, 849–856 (1994).
Reddy, M.P. et al. J. Immunol. 164, 1925–1933 (2000).
Cole, M.S. et al. J. Immunol. 159, 3613–3621 (1997).
Beevenhouwer, D.O. Infect. Immun. 75, 1424–1435 (2007).
The workshop slides from Patrick G. Swann are available at www.aapspharmaceutica.com/meetings/files/57/swannho.pdf
Weinberg, W.C. et al. Cancer Metastasis Rev. 24, 569–584 (2005).
Dillon, T.M. et al. J. Chromatogr. A. 1053, 299–306 (2004).
Alyanakian, M.-A. et al. Vox Sang. 84, 188–192 (2003).
WHO Review of the notation for the allotypic and related markers of human immunoglobulins. Eur. J. Immunol. 6, 599–601 (1976).
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J.S. works for Abbott Laboratories, a global healhcare company.
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Salfeld, J. Isotype selection in antibody engineering. Nat Biotechnol 25, 1369–1372 (2007). https://doi.org/10.1038/nbt1207-1369
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DOI: https://doi.org/10.1038/nbt1207-1369
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