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Where have all the antibiotic patents gone?

Patent and regulatory hurdles combined with low returns on investment are stifling antibiotic R&D in the pharmaceutical industry.

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Figure 1: Antibacterial sales forecasts from 2005 to 2015, and key patent expirations.

References

  1. Bad bugs, no drugs: as antibiotic R&D stagnates... a public health crisis brews (Infectious Diseases Society of America, Alexandria, Virginia, 2004).

  2. Utility Examination Guidelines, 66 Fed. Reg. 1092 http://www.uspto.gov/web/officer/com/sol/notices/utilexmguide.pdf (2001).

  3. Tufts Center for the Study of Drug Development pegs cost of a new prescription medicine at $802 million. http://csdd.tufts.edu/NewsEvents/RecentNews.asp?newsid=6 (2001).

  4. Fermini, B. & Fossa, A.A. Nat. Rev. Drug Discov. 2, 439–447 (2003).

    Article  CAS  Google Scholar 

  5. Harris, G. Approval of antibiotic worried safety officials. New York Times (19 July 2006).

    Google Scholar 

  6. FDA rejects Replidyne drug application. Denver Business Journal (23 October 2006).

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Katz, M., Mueller, L., Polyakov, M. et al. Where have all the antibiotic patents gone?. Nat Biotechnol 24, 1529–1531 (2006). https://doi.org/10.1038/nbt1206-1529

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