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Putting the opium in poppy to sleep

A genetically modified opium poppy produces a pharmaceutical precursor instead of morphine and codeine.

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Figure 1: In aerial parts of the opium poppy, including unripe seed capsules (background), the analgesic alkaloids morphine and codeine are synthesized from the amino acid tyrosine via multiple enzymatic steps, with reticuline as an intermediate.

Bob Crimi

References

  1. 1

    Allen, R.S. et al. Nat. Biotechnol. 22, 1559–1566 (2004).

    CAS  Article  Google Scholar 

  2. 2

    Mello, C.C. & Conte D. Jr. Nature 431, 338–342 (2004).

    CAS  Article  Google Scholar 

  3. 3

    Facchini, P.J. Annu. Rev. Plant Physiol. Plant Mol. Biol. 52, 29–66 (2001).

    CAS  Article  Google Scholar 

  4. 4

    Memelink, J., Verpoorte, R. & Kijne, J.W. Trends Plant Sci. 6, 212–219 (2001).

    CAS  Article  Google Scholar 

  5. 5

    De Luca, V. & St. Pierre, B. Trends Plant Sci. 5, 168–173 (2000).

    CAS  Article  Google Scholar 

  6. 6

    Unterlinner, B., Lenz, R. & Kutchan, T.M. Plant J. 18, 465–475 (1999).

    CAS  Article  Google Scholar 

  7. 7

    Winkel, B.S.J. Annu. Rev. Plant Biol. 55, 85–107 (2004).

    CAS  Article  Google Scholar 

  8. 8

    Achnine, L., Blancaflor, E.B., Rasmussen, S. & Dixon, R.A. Plant Cell 16, 3098–3109 (2004).

    CAS  Article  Google Scholar 

  9. 9

    Bird, D.A., Franceschi, V.R. & Facchini, P.J. Plant Cell 15, 2626–2635 (2003).

    CAS  Article  Google Scholar 

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Memelink, J. Putting the opium in poppy to sleep. Nat Biotechnol 22, 1526–1527 (2004). https://doi.org/10.1038/nbt1204-1526

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