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Mending the message

An ancient, archaeal splicing endonuclease provides a promising alternative for gene therapy.

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Figure 1: Three ways to amend a message.

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Competing interests

M.A.G.-B. is a scientific founder and consultant to Intronn (Gaithersburg, MD), a company that is commercializing spliceosome-mediated trans-splicing.

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Garcia-Blanco, M. Mending the message. Nat Biotechnol 21, 1448–1449 (2003). https://doi.org/10.1038/nbt1203-1448

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