T cells genetically modified to express a peptide–MHC complex, normally involved in the induction of autoimmunity, can kill pathogenic T cells and inhibit autoimmune disease.
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References
Jyothi, M., Flavell, R. & Geiger, T. Nat. Biotechnol., 1215–1220 (2002).
Kuchroo, V.K. et al. Annu. Rev. Immunol. 20, 101–123 (2002).
Vanderlugt, C.L. & Miller, S.D. Nat. Rev. Immunol. 2, 85–95 (2002).
Nicholson, L.A., Murtaza, A., Hafler, B.P., Sette, A. & Kuchroo, V.K. Proc. Natl. Acad. Sci. USA 94, 9279–9284 (1997).
Hosken, N., Shibuya, K., Heath, A., Murphy, K. & O'Garra, A. J. Exp. Med. 182, 1579–1584 (1995).
Nicholson, L.B. et al. Proc. Natl. Acad. USA 95, 264–269 (1998).
Nicholson, L., Greer, J., Sobel, R., Lees, M. & Kuchroo, V. Immunity 3, 397–405 (1995).
Munder, M. et al. J. Exp. Med. 196, 1151–1162 (2002).
Bielekova, B. et al. Nat. Med. 6, 1167–1175. (2000).
Kappos, L. et al. Nat. Med. 6, 1176–1182. (2000).
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Wahren-Herlenius, M., Kuchroo, V. Killers come to the rescue. Nat Biotechnol 20, 1205–1206 (2002). https://doi.org/10.1038/nbt1202-1205
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DOI: https://doi.org/10.1038/nbt1202-1205
