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Moving agbiotech downstream

Abstract

Companies must turn to effective process development as a competitive weapon in agricultural biotechnology.

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Figure 1: Project management chart outlining the timing of the various development stages for a hypothetical transgenic corn product.
Figure 2: Outline of the breeding process for a transgenic corn product.
Figure 3: Overview of breeding of a transgenic corn product.

References

  1. Pisano, G.P. The development factory. (Harvard Business School Press, Boston, MA; 1997).

    Google Scholar 

  2. Mazur, B.J. Commercializing the products of plant biotechnology. Trends Biotechnol. 13, 319–323. (1995).

    Article  CAS  Google Scholar 

  3. Diehn, S.H., De Rocher E.J. & Green, P.J. Problems that can limit the expression of foreign genes in plants: lessons to be learned from B.t. toxin genes. in Genetic engineering, Vol. 18. (ed. Setlow, J.K.) 83–99 (Plenum Press, New York; 1996).

    Chapter  Google Scholar 

  4. Duke, S.O. Herbicide-resistant crops: agricultural, environmental, economic, regulatory, and technical aspects. (Lewis Publishers, 1996).

    Google Scholar 

  5. Gebhardt, C. Plant genes for pathogen resistance—variations on a theme. Trends Pharmacol. Sci. 2, 243–244 (1997).

    Article  Google Scholar 

  6. Ingram, J. & Bartels, D. The molecular basis of dehydration tolerance in plants. Annu. Rev. Plant Physiol. Plant Mol. Biol. 47, 377–403 (1996).

    Article  CAS  Google Scholar 

  7. Horner, H.T. & Palmer, R.G. Mechanisms of genic male sterility. Crop Sci. 35, 1527–1535 (1995).

    Article  Google Scholar 

  8. Herbers, K. & Sonnewald, U. Manipulating metabolic partitioning in transgenic plants. Trends Biotechnol. 14,198–205 (1996).

    Article  CAS  Google Scholar 

  9. Ohlrogge, J.B. Design of new plant products: engineering fatty acid metabolism. Plant Physiol. 104, 821–826 (1994).

    Article  CAS  Google Scholar 

  10. Cook, M.L. Structural changes in the U.S. grain and oilseed sector. In Food and agricultural markets: the quiet revolution. (eds Schertz, L.P. & Daft L.M.) ′–′ (National Policy Association, Food and Agricultural Committee, 1994).

    Google Scholar 

  11. Register, J.C. : Approaches to evaluating the transgenic status of transformed plants. Trends Biotechnol. 15, 141–146 (1997).

    Article  CAS  Google Scholar 

  12. Hill, W.G. Variation in genetic composition in backcrossing programs. J. Heredity 84, 212–213 (1993).

    Article  Google Scholar 

  13. Hillel, J. et al. DNA fingerprints applied to gene introgression in breeding programs. Genetics 124, 783–789 (1990).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Hospital, F, Chevalet, C. & Mulsant, P. Using markers in genetic introgression breeding programs. Genetics 132, 1199–1210 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Apel, A. Monsanto, Limagrain recall genetically engineered RR canola seed. Seed Crop Digest 6, 23 (1997).

    Google Scholar 

Download references

Acknowledgements

I would like to thank Alan Blower, Elizabeth Earle, and Peggy Lemaux for reviewing the manuscript and for their helpful comments. I am is grateful to Gary Pisano for allowing me to borrow heavily from his book The Development Factory.

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McElroy, D. Moving agbiotech downstream. Nat Biotechnol 17, 1071–1074 (1999). https://doi.org/10.1038/15054

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