Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device

Abstract

Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Images of the microchip reservoirs and implantable drug delivery system.
Figure 2: Summary of in vivo results.

References

  1. Langer, R. Sci. Am. 288, 50–57 (2003).

    Article  Google Scholar 

  2. LaVan, D.A., McGuire, T. & Langer, R. Nat. Biotechnol. 21, 1184–1191 (2003).

    CAS  Article  Google Scholar 

  3. Shastri, V.P. Curr. Pharm. Biotechnol. 4, 331–337 (2003).

    CAS  Article  Google Scholar 

  4. Urquhart, J. J. Intern. Med. 248, 357–376 (2000).

    CAS  Article  Google Scholar 

  5. Scavini, M. et al. Diabetes Care 20, 610–613 (1997).

    CAS  Article  Google Scholar 

  6. Okada, H. et al. Pharm. Res. 8, 787–791 (1991).

    CAS  Article  Google Scholar 

  7. Cukierski, M.J., Johnson, P.A. & Beck, J.C. Int. J. Toxicol. 20, 369–381 (2001).

    CAS  Article  Google Scholar 

  8. Maloney, J.M. et al. J. Control. Release 109, 244–255 (2005).

    CAS  Article  Google Scholar 

  9. Santini, J.T., Cima, M.J. & Langer, R. Nature 397, 335–337 (1999).

    CAS  Article  Google Scholar 

  10. Li, Y. et al. J. Control. Release 106, 138–145 (2005).

    CAS  Article  Google Scholar 

  11. Werkmeister, J., Tebb, T., White, J. & Ramshaw, J. Curr. Opin. Solid State Mater. Sci. 5, 185–191 (2001).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

We thank Zouhair Sbiaa and Michael Finot (Micralyne) for producing the microchips used in this study, and all members of the MicroCHIPS team, past and present, who participated in developing this technology and in the practical demonstration of its utility in vivo.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John T Santini Jr..

Ethics declarations

Competing interests

The authors are current or former employees of MicroCHIPS, Inc. and possess stock or stock options in MicroChips, Inc.

Supplementary information

Supplementary Fig. 1

In vitro leuprolide release kinetics. (PDF 14 kb)

Supplementary Methods (PDF 27 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Prescott, J., Lipka, S., Baldwin, S. et al. Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device. Nat Biotechnol 24, 437–438 (2006). https://doi.org/10.1038/nbt1199

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt1199

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing