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Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device


Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry.

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Figure 1: Images of the microchip reservoirs and implantable drug delivery system.
Figure 2: Summary of in vivo results.


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We thank Zouhair Sbiaa and Michael Finot (Micralyne) for producing the microchips used in this study, and all members of the MicroCHIPS team, past and present, who participated in developing this technology and in the practical demonstration of its utility in vivo.

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Correspondence to John T Santini Jr..

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The authors are current or former employees of MicroCHIPS, Inc. and possess stock or stock options in MicroChips, Inc.

Supplementary information

Supplementary Fig. 1

In vitro leuprolide release kinetics. (PDF 14 kb)

Supplementary Methods (PDF 27 kb)

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Prescott, J., Lipka, S., Baldwin, S. et al. Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device. Nat Biotechnol 24, 437–438 (2006).

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