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How do RNA folding algorithms work?

Nature Biotechnology volume 22, pages 14571458 (2004) | Download Citation


Programs such as MFOLD and ViennaRNA are widely used to predict RNA secondary structures. How do these algorithms work? Why can't they predict RNA pseudoknots? How accurate are they, and will they get better?

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  1. 1.

    Calculating nucleic acid secondary structure. Curr. Opin. Struct. Biol. 10, 303–310 (2000).

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  1. Sean R. Eddy is at Howard Hughes Medical Institute & Department of Genetics, Washington University School of Medicine, 4444 Forest Park Blvd., Box 8510, Saint Louis, Missouri 63108, USA.

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