Transgenic plants as factories for biopharmaceuticals

Abstract

Plants have considerable potential for the production of biopharmaceutical proteins and peptides because they are easily transformed and provide a cheap source of protein. Several biotechnology companies are now actively developing, field testing, and patenting plant expression systems, while clinical trials are proceeding on the first biopharmaceuticals derived from them. One transgenic plant-derived biopharmaceutical, hirudin, is now being commercially produced in Canada for the first time. Product purification is potentially an expensive process, and various methods are currently being developed to overcome this problem, including oleosin-fusion technology, which allows extraction with oil bodies. In some cases, delivery of a biopharmaceutical product by direct ingestion of the modified plant potentially removes the need for purification. Such biopharmaceuticals and edible vaccines can be stored and distributed as seeds, tubers, or fruits, making immunization programs in developing countries cheaper and potentially easier to administer. Some of the most expensive biopharmaceuticals of restricted availability, such as glucocerebrosidase, could become much cheaper and more plentiful through production in transgenic plants.

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Acknowledgements

Our thanks to the UK Department of Transport, Environment and the Regions (DETR), who funded this work as part of their program on risk assessment for the release of genetically modified plants.

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Correspondence to Glynis Giddings.

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Giddings, G., Allison, G., Brooks, D. et al. Transgenic plants as factories for biopharmaceuticals. Nat Biotechnol 18, 1151–1155 (2000). https://doi.org/10.1038/81132

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