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Automated solid phase synthesis of small organic molecules

A new instrument promises to automate a broad range or chemical synthetic procedures.

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References

  1. Leznoff, C.C. and Fyles, T.M. 1976. J. Chem. Soc. Chem. Comms., pp. 251–252.

  2. Merrifield, R.B. 1962. Fed. Proc.21: 412.

    Google Scholar 

  3. Merrifield, R.B. 1963. J. Amer. Chem. Soc. 85: 2149–2154.

    Article  CAS  Google Scholar 

  4. Merrifield, R.B. 1965. Nature 207: 522–523.

    Article  CAS  Google Scholar 

  5. Merrifield, R.B. 1965. Science 150: 178–185.

    Article  CAS  Google Scholar 

  6. Merrifield, R.B., Stewart, J.M. and Jernberg, N. 1966. Anal. Chem. 38: 121–140.

    Article  Google Scholar 

  7. J.W, Stewart, personal communication

  8. Cook, R.M., Hudson, D., Mayran, E. and Ott, J. 1982, pp. 111–124 in Chemical and Enzymatic Synthesis of Gene Fragments-A Laboratory Manual. Gussen, H.G. and Lang, A. (eds.). Verlag Chemie, Weinham.

    Google Scholar 

  9. Heron, E.J. 1984. An. Biotechnol. Lab. 2: 52–59.

    CAS  Google Scholar 

  10. Kent, S.B.H., Hood, L.E., Beilan, H., Meister, S. and Geyser, T. 1984. pp. 185–188 in Peptides 1984— Proceedings of the 18th European Peptide Symposium.Almqvist & Wiksell, Stockholm.

    Google Scholar 

  11. Schnorrenberg, G. and Gerhardt, H. 1989. Tetrahedron 45: 7759–7764.

    Article  CAS  Google Scholar 

  12. Gauspohl, H., Kraft, M., Boulin, C. and Frank, R. 1990. pp 1003–1004 in Peptides: Chemistry, Structure and Biology, Proceedings of the 11th American Peptide Symposium,,Rivier, J and Marshall, G. (eds.). ESCOM, Leiden.

  13. Zuckerman, R.N., Kerr, J.M., Siani, M.A. and Banville, S.C. .C. 1976. Int. J. Pept. Protein Res. 40: 497–506.

    Article  Google Scholar 

  14. Members of this product development consortium included Abbott, Amgen, Berlex, Bristol-Myers Squibb, Merck, Pharmacopeia, Sandoz and Smith Kline Beecham.

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Hoeprich, P. Automated solid phase synthesis of small organic molecules. Nat Biotechnol 14, 1311–1313 (1996). https://doi.org/10.1038/nbt1096-1311

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