Linker Technology: Antibody-Mediated Delivery Systems

Article metrics

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Köhler, G. and Milstein, C. 1975. Continuous cultures of fused cells secreting antibody of pre-defined specificity. Nature 256: 495.

  2. 2

    Dixon, B. The industrial revolution in monoclonals. Bio/Technology 2: 26.

  3. 3

    Gallego, J., Price, M.R. and Baldwin, R.W. 1984. Preparation of four daunomycin-monoclonal antibody 791T/36 conjugates with anti-tumor activity. International Journal of Cancer 33: 737.

  4. 4

    Levy, R., Stratte, P., Link, M., Maloney, D.G., Oseroff, A. and Miller, R.A. 1984. Monoclonal antibodies to human lymphocytes, p. 193 in Monoclonal Antibodies and Functional Cell Lines. Progress and Applications. R. H. Kennett, K. B. Bechtol, and T.J. McKearn (eds.), Plenum Press, New York.

  5. 5

    Poste, G. and Kirsh, R. 1983. Site-specific (targeted) drug delivery in cancer therapy. Bio/Technology 1: 869.

  6. 6

    Berthold, F. 1984. Monoclonal antibodies to human neuroblastoma cells and other solid tumors, p. 215 in Monoclonal Antibodies and Functional Cell Lines. Progress and Applications. R. H. Kennett, K. B. Bechtol, and T.J. McKearn (eds.), Plenum Press, New York.

  7. 7

    Buck, D.W., Larrick, J.W., Raubitschek, A., Truitt, K.E., Senyk, G., Wang, J. and Dyer, B.J. 1984. Production of human monoclonal antibodies, p. 275 in Monoclonal Antibodies and Functional Cell Lines. Progress and Applications. R. H. Kennett, K. B. Bechtol, and T.J. McKearn (eds.), Plenum Press, New York.

  8. 8

    Price, H.S. 1985. Regulatory reflections. Bio/Technology 3: 272.

  9. 9

    Hopkinson, J. 1985. Hollow fiber cell culture systems for economical cell-product manufacturing. Bio/Technology 3: 225.

  10. 10

    Means, G.E. and Feeney, R.E. 1971. Chemical Modification of Proteins. Holden-Day, Inc., San Francisco.

  11. 11

    IUPAC/IUB Commission on Biochemical Nomenclature. 1968.

  12. 12

    Quash, G., Roch, A.M., Niveleau, A., Grange, J., Keolouangkhot, T. and Huppert, J. 1978. The preparation of latex particles with covalently bound polyamines, IgG, and measles agglutination and their use in visual agglutination tests. J. Immunol. Meth. 22: 165.

  13. 13

    Chua, M.M., Fan, S.T. and Karush, F. 1984. Attachment of immunoglobulin to liposomal membrane via protein carbohydrate. Biochem. Biophys. Acta 800: 291.

  14. 14

    Alvarez, V.L., Lee, C., Rodwell, J.D., Foss, P.A. and Goers, J.W.F. 1984. Fluorescein thiosemicarbazide: a selective fluorescent label for glycoproteins. Fed. Proc. Abstr. 43: 3602.

  15. 15

    Rodwell, J.D., Lee, C., Ferguson, A., Wen, M.L. and Tollock, B. 1984. Site-specific monoclonal antibody modification: retention of affinity and unique binding specificity. Fed. Proc. Abstr. 43: 2084.

  16. 16

    Eisen, H.N. and McGuigan, J.E. 1971. Quenching of antibody fluorescence by haptens and antigens: a method for determining antibody-ligand affinity, p. 395 in Methods in Immunology and Immunochemistry, Vol. 3. C. A. Williams and M. W. Chase (eds.), Academic Press, New York.

  17. 17

    Rodwell, J.D., Gearhart, P.J. and Karush, F. 1983. Restriction in IgM expression IV. Affinity analysis of monoclonal anti-phosphorylcholine antibodies. J. Immunol. 130: 313.

  18. 18

    Sips, R. 1948. On the structure of catalyst surface. J. Chem. Phys. 16: 490.

  19. 19

    Ehrlich, P. 1908. Uber den jetzigen Stand der Karzinomforschung, p. 550 in The Collected Papers of Paul Ehrlich, Vol. II. Pergamon Press, London (1957).

  20. 20

    Sartorelli, A.C., Lazo, J.S. and Bertino, J.R. (eds.). 1981. Molecular Actions and Targets for Cancer Chemotherapeutic Agents. Academic Press, New York.

  21. 21

    Baldwin, R.W., Durrant, L., Embleton, M.J., Garnett, M., Pimm, M.V., Robins, R.A., Hardcastle, J.D., Armitage, N. and Ballantyne, K. 1985. Design and therapeutic evaluation of monoclonal antibody 791T/36-methotrexate conjugates. UCLA Symposium: Monoclonal Antibodies and Cancer Therapy. (In press.)

  22. 22

    Moldofsky, P.J., Sears, H.F., Mulhearn, C.B., Jr., Hammond, N.D., Powe, J., Gatenby, R.A., Steplewski, Z. and Koprowsky, H. 1984. Detection of metastatic tumor in normal-sized retroperitoneal lymph nodes by monoclonal antibody imaging. New England Journal of Medicine. 311: 106.

  23. 23

    Lamb, J.F. and Kramer, H.H. 1983. Commercial production of radioisotopes for nuclear medicine, p. 17 in Radiotracers for Medical Applications, Vol. I G. V. S. Rayudu (ed.), CRC Press, Boca Raton, FL.

  24. 24

    Lee, C., McKearn, T.J., Rodwell, J.D., Hiles, B.L. and Alvarez, V.L. 1984. Radioimmunoimaging with site-specifically modified monoclonal antibodies. Fed. Proc. Abstr. 43: 3014.

Download references

Author information

  1. John D. Rodwell, Ph.D., Director, Chemical Research, and Thomas J. McKearn, M.D., Ph.D., Vice President, Research and Development, Cytogen Corp., Princeton, NJ 08540

    Rights and permissions

    Reprints and Permissions

    About this article

    Cite this article

    Rodwell, J., McKearn, T. Linker Technology: Antibody-Mediated Delivery Systems. Nat Biotechnol 3, 889–894 (1985) doi:10.1038/nbt1085-889

    Download citation

    Further reading