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Epigenomics reveals a functional genome anatomy and a new approach to common disease

Nature Biotechnology volume 28, pages 1049–1052 (2010)Cite this article

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Epigenomics provides the context for understanding the function of genome sequence, analogous to the functional anatomy of the human body provided by Vesalius a half-millennium ago. Much of the seemingly inconclusive genetic data related to common diseases could therefore become meaningful in an epigenomic context.

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Figure 1: The rate of increase of genome-scale publications addressing cancer genetics has become greater than that of publications in the same area focused on selected genes.

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Acknowledgements

I thank E. Pujadas, K. Reddy and R. Ohlsson for comments on the manuscript. This work was supported by US National Institutes of Health grant 5R37CA054358.

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  1. Andrew P. Feinberg is at the Center for Epigenetics and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.,

    Andrew P Feinberg

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  1. Andrew P Feinberg
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Correspondence to Andrew P Feinberg.

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Feinberg, A. Epigenomics reveals a functional genome anatomy and a new approach to common disease. Nat Biotechnol 28, 1049–1052 (2010). https://doi.org/10.1038/nbt1010-1049

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