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Linking cell signaling and the epigenetic machinery

Nature Biotechnology volume 28, pages 1033–1038 (2010)Cite this article

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One of the biggest gaps in our knowledge about epigenomes is how their interplay with cellular signaling influences development, adult cellular differentiation and disease.

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Figure 1: Depiction of potential cell signaling in Waddington's model of epigenetic determination of development, as interpreted by Hochedlinger and Plath7.
Figure 2: Potential mechanisms by which the chromatin of key developmental genes may be regulated by cellular signaling.
Figure 3: Modeling signaling that may promote cancer-specific DNA hypermethylation imposed on a normally non-DNA methylated, PcG-marked gene.

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  1. Helai P. Mohammad and Stephen B. Baylin are at the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.,

    Helai P Mohammad & Stephen B Baylin

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Mohammad, H., Baylin, S. Linking cell signaling and the epigenetic machinery. Nat Biotechnol 28, 1033–1038 (2010). https://doi.org/10.1038/nbt1010-1033

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