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Cancer's insatiable appetite

Seemingly unrelated mutations that drive cancer share the ability to promote nutrient uptake and metabolism conducive to cell growth.

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Figure 1: Genetic events shown to be important in human cancer influence signal transduction through a complex network that results in inappropriate cell proliferation.


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Correspondence to Lewis C Cantley or Matthew G Vander Heiden.

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Competing interests

J.W.L. has no competing financial interests. L.C.C. and M.G.V.H. hold various patents on targeting metabolism in cancer and have financial interests in Agios Pharmaceuticals, which seeks to exploit alterations in cancer metabolism for novel therapeutics.

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Locasale, J., Cantley, L. & Heiden, M. Cancer's insatiable appetite. Nat Biotechnol 27, 916–917 (2009).

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