Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

siRNA delivery not Toll-free

Activating the tumor-associated immune system with an siRNA conjugated to a Toll-like receptor 9 ligand is a promising anticancer strategy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: TLR9-mediated RNAi in the tumor microenvironment.

Kim Caesar


  1. Aouadi, M. et al. Nature 458, 1180–1184 (2009).

    Article  CAS  Google Scholar 

  2. MacDiarmid, J.A. et al. Nat. Biotechnol. 27, 643–651 (2009).

    Article  CAS  Google Scholar 

  3. Peer, D. et al. Science 319, 627–630 (2008).

    Article  CAS  Google Scholar 

  4. Poeck, H. et al. Nat. Med. 14, 1256–1263 (2008).

    Article  CAS  Google Scholar 

  5. Sato, Y. et al. Nat. Biotechnol. 26, 431–442 (2008).

    Article  CAS  Google Scholar 

  6. Kortylewski, M. et al. Nat. Biotechnol. 27, 925–932 (2009).

    Article  CAS  Google Scholar 

  7. Marques, J.T. & Williams, B.R. Nat. Biotechnol. 23, 1399–1405 (2005).

    Article  CAS  Google Scholar 

  8. Kleinman, M.E. et al. Nature 452, 591–597 (2008).

    Article  CAS  Google Scholar 

  9. Kortylewski, M. et al. Nat. Med. 11, 1314–1321 (2005).

    Article  CAS  Google Scholar 

  10. McNamara, J.O. II et al. Nat. Biotechnol. 24, 1005–1015 (2006).

    Article  CAS  Google Scholar 

  11. MacDiarmid, J.A. et al. Cancer Cell 11, 431–445 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Bryan R G Williams.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gantier, M., Williams, B. siRNA delivery not Toll-free. Nat Biotechnol 27, 911–912 (2009).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing