Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Complementary therapies for inflammation

Monoclonal antibodies against the human C5a receptor offer new therapeutic prospects for complement inhibition.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A simplified scheme of the complement activation cascade shows that C3 and C5 are critical convergence points of four activation pathways and indicates potential targets of anti-inflammatory drugs.

Katie Ris

References

  1. Lee, H. et al. Nat. Biotechnol. 24, 1279–1284 (2006).

    Article  CAS  Google Scholar 

  2. Huber-Lang, M. et al. Nat Med. 12, 682–687 (2006).

    Article  CAS  Google Scholar 

  3. Wang, Y., Rollins, S.A., Madri, J.A. & Matis, L.A. Proc. Natl. Acad. Sci. USA 92, 8955–8959 (1995).

    Article  CAS  Google Scholar 

  4. Thomas, T.C. et al. Mol. Immunol. 33, 1389–1401 (1996).

    Article  CAS  Google Scholar 

  5. Frei, Y., Lambris, J.D. & Stockinger, B. Mol. Cell Probes 1, 141–149 (1987).

    Article  CAS  Google Scholar 

  6. Peng, T. et al. J. Clin. Invest. 115, 1590–1600 (2005).

    Article  CAS  Google Scholar 

  7. Gerard, N.P. et al. J. Biol. Chem. 280, 39677–39680 (2005).

    Article  CAS  Google Scholar 

  8. Kohl, J. et al. J. Clin. Invest. 116, 783–796 (2006).

    Article  CAS  Google Scholar 

  9. Dobrina, A. et al. Blood 99, 185–192 (2002).

    Article  CAS  Google Scholar 

  10. Hillmen, P. et al. N. Engl. J. Med. 355, 1233–1243 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, Y. Complementary therapies for inflammation. Nat Biotechnol 24, 1224–1226 (2006). https://doi.org/10.1038/nbt1006-1224

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt1006-1224

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing