Ion channels can be inshibited by polyclonal antibodies targeted to a specific extracellular loop.
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Benham, C. Simple recipe for blocking ion channels. Nat Biotechnol 23, 1234–1235 (2005). https://doi.org/10.1038/nbt1005-1234
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DOI: https://doi.org/10.1038/nbt1005-1234