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Antibodies in the breakdown lane

An engineered IgG induces degradation of endogenous IgG, providing a potential therapeutic approach to autoimmune disease.

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Figure 1: FcRn normally protects IgG from degradation by diverting endogenous IgG from lysosomes.

Bob Crimi


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Blumberg, R., Lencer, W. Antibodies in the breakdown lane. Nat Biotechnol 23, 1232–1234 (2005).

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