Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

An enlightened genetic switch

Nature Biotechnology volume 20, pages 985–987 (2002)Cite this article

Development of a genetic switch based on a photosensitive protein signals the beginning of light-based biological engineering.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Generic light-switchable promoter system.

References

  1. Shimizu-Sato, S. et al. Nat. Biotechnol. 20, 1041–1044 (2002).

    Article  CAS  Google Scholar 

  2. Gambetta, G.A & Lagarias, J.C. Proc. Natl. Acad. Sci. USA. 11, 10566–10571 (2001).

    Article  Google Scholar 

  3. Gardner, T.S., Cantor, C.R. & Collins, J.J. Construction of a genetic toggle switch in Escherichia coli. Nature 403, 339–342 (2000).

    Article  CAS  Google Scholar 

  4. Rossi, F.M., Blakely, B.T., Charlton, C.A. & Blau, H.M. Methods Enzymol. 328, 231–251 (2001).

    Article  Google Scholar 

  5. Galarneau, A., Primeau, M., Trudeau, L.E. & Michnick, S.W. Nat Biotechnol. 20, 619–622 (2002).

    Article  CAS  Google Scholar 

  6. Subramaniam, R., Desveaux, D., Spickler, C., Michnick, S.W., & Brisson, N. Nat. Biotechnol. 19, 769–772 (2001).

    Article  CAS  Google Scholar 

  7. Spencer, D.M., Wandless, T.J., Schreiber, S.L. & Crabtree, G.R. Science. 262, 1019–1024 (1993).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. research fellow at the Molecular Sciences Institute, 2168 Shattuck Ave, 2nd Floor, Berkeley, 94704, CA

    Andrew R. Mendelsohn

Authors
  1. Andrew R. Mendelsohn
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mendelsohn, A. An enlightened genetic switch. Nat Biotechnol 20, 985–987 (2002). https://doi.org/10.1038/nbt1002-985

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt1002-985

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing