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Seeking sweet relief for diabetes

Nature Biotechnology volume 20, pages 977–981 (2002)Cite this article

An Erratum to this article was published on 01 February 2003

Diabetes is a modern-day epidemic in the making, but drug developers are still undecided over the best strategy for its treatment.

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Figure 1: The disturbing face of diabetes.
Figure 2: Targets for treatments for type 2 diabetes.

References

  1. Data taken from US Centers for Disease Control web site, http://www.cdc.gov/diabetes.

  2. American Diabetes Association. Economic consequences of diabetes mellitus in the US in 1997. Diabetes Care 21, 296–309 (1998).

  3. Knowler, W.C. et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 346, 393–403 (2002).

    Article  CAS  Google Scholar 

  4. Barroso, I. et al. Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 402, 880–883 (1999).

    Article  CAS  Google Scholar 

  5. Fletcher, L. Oral insulin deal for Nobex. Nat. Biotechnol. 20, 645 (2002).

  6. Steppan, C.M. et al. The hormone resistin links obesity to diabetes. Nature 409, 307–312 (2002).

    Article  Google Scholar 

  7. Sesti, G. Searching for type 2 diabetes genes: prospects in pharmacotherapy. Pharmacogenomics J. 2, 25–29 (2002).

    Article  CAS  Google Scholar 

  8. Lumelsky, N. et al. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292, 1389–1394 (2001).

    Article  CAS  Google Scholar 

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Authors
  1. Alan Dove
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Dove, A. Seeking sweet relief for diabetes. Nat Biotechnol 20, 977–981 (2002). https://doi.org/10.1038/nbt1002-977

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