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The bittersweet promise of glycobiology

Carbohydrates play a wide range of important roles in the body and, despite the challenges posed by glycobiology, are now tempting targets for drug developers.

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Figure 1: A simplified diagram showing the synthesis of an N-linked glycan.

© Bob Crimi

References

  1. Plante, O.J., Palmacci, E.R. & Seeberger, P.H. Automated solid-phase synthesis of oligosaccharides. Science 291, 1523–1527 (2001).

    Article  CAS  Google Scholar 

  2. Barton, W.A. et al. Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization. Nat. Struct. Biol. 8, 545–551 (2001).

    Article  CAS  Google Scholar 

  3. Weikert, S. et al. Engineering Chinese hamster ovary cells to maximize sialic acid content of recombinant glycoproteins. Nat. Biotechnol. 17, 1116–1121 (2001).

    Article  Google Scholar 

  4. Zitzmann, N. et al. Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents. Proc. Natl. Acad. Sci. USA 12, 11878–11882 (1999).

    Article  Google Scholar 

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Dove, A. The bittersweet promise of glycobiology. Nat Biotechnol 19, 913–917 (2001). https://doi.org/10.1038/nbt1001-913

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