Scalable and parallel experimental strategies, collectively referred to as "functional genomics," aim to analyze sequence homology, identify protein–protein interactions, and measure gene expression on a genome-wide scale. In this issue, Cismowski and colleagues (p. 906) describe the development of a function-based genomic screen in yeast to identify genes whose products modulate an important mammalian signaling pathway, the G-protein coupled receptor pathway.
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Frederickson, R. Human genes find function in yeast. Nat Biotechnol 17, 840 (1999). https://doi.org/10.1038/12813
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DOI: https://doi.org/10.1038/12813