Research Paper | Published:

Antibiotic TA: An Adherent Antibiotic

Bio/Technology volume 2, pages 796799 (1984) | Download Citation

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Abstract

Antibiotic TA adheres avidly to a variety of surfaces. When administered orally or intravenously to animals, the antibiotic concentrates in an active form close to the site of administration. No measurable blood level of the antibiotic is found. Tissues treated with antibiotic TA and then washed continuously to remove unbound antibiotic retain bactericidal activity. Antibiotic TA may have applications in circumstances where an active bound antibiotic is desired.

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References

  1. 1.

    , and 1973. Bactericidal action of an antibiotic produced by Myxococcus xanthus. Antimicrob. Agents Chemother. 4: 507–513.

  2. 2.

    , and 1974. Purification and partial characterization of an antibiotic produced by Myxoroccus xanthus. Can. J. Microbiol. 20: 155–101.

  3. 3.

    , , and 1983. Amino acid precursors of Myxocococcus xanthus antibiotic TA. J. Antibiot. 36: 1525–1530.

  4. 4.

    , and 1981. Mode of action of Myxococcus xanthus antibiotic TA. Antimicrob. Agents Chemother. 19: 349–351.

  5. 5.

    , , and 1982. Chemical properties of Myxocuccus xanthus antibiotic TA. J. Antibiot. 35: 788–793.

  6. 6.

    1967. Experimental pyelonephritis: XIII. On the ability of water diuresis to induce susceptibility to E.coli bacteriuria in normal rat. Yale J. Biol. Med. 39: 255.

  7. 7.

    1970. Binding of antibiotics to tissue homogenates. J. Infect. Dis. 121: 55–64.

  8. 8.

    and 1971. Binding of polymyxin antibiotics to tissues: the major determinant of distribution and persistence in the body. J. Infect. Dis. 124: 394–400.

  9. 9.

    1980. Urinary tract infections. Surgical Clinics of North America 60: 223–231.

  10. 10.

    and 1976. Conversion of penicillin to cephalosporins by cell-free extracts of Cephahsporium acremonium. Biochem. Biophys. Res. Comm. 70: 405–473.

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Author information

Affiliations

  1. Department of Microbiology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel

    • E. Rosenberg
    • , J. M. Porter
    • , P. N. Nathan
    • , A. Manor
    •  & M. Varon

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DOI

https://doi.org/10.1038/nbt0984-796

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