Abstract
The use of FAB and FD as well as EI mass spectrometry for the determination of antibiotic structures is described. Neomycins, scopafungin, polyenic macrolides, alamethicins, emerimicins, and antiamoebins proved to be amenable to FD analysis while the capability of FAB is demonstrated with zwitterionic tetraenes, and zervamicins. Due to the well characterized fragmentations it produces, EI is used whenever the sample or its degradation products are sufficiently volatile.
*E. R. Squibb lectures on Chemistry of Microbial Products presented at Waksman Institute of Microbiology, Rutgers University, New Brunswick, NJ, 16, March 1983.
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Rinehart, K. Newer Methods for Characterization of Antibiotics II. Antibiotic Structure Studied by Mass Spectrometry. Nat Biotechnol 1, 581–588 (1983). https://doi.org/10.1038/nbt0983-581
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DOI: https://doi.org/10.1038/nbt0983-581
