The US Food and Drug Administration approved in July Ruconest (C1 esterase inhibitor) in adults and adolescents with acute attacks of hereditary angioedema (HAE). The product, the first approved C1-esterase inhibitor manufactured in recombinant form, is purified from the milk of transgenic rabbits and restores levels of functional C1-esterase inhibitor in the plasma of patients, thereby reducing swelling often seen in the abdomens, extremities and faces of HAE sufferers. The drug is produced by Leiden, the Netherlands–based Pharming Group partnered with Salix Pharmaceuticals of Raleigh, North Carolina.
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Rabbit milk Ruconest for hereditary angioedema. Nat Biotechnol 32, 849 (2014). https://doi.org/10.1038/nbt0914-849d