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Pushing the envelope on HIV-1 neutralization

The identification of broadly neutralizing monoclonal antibodies against HIV-1 may aid efforts to design a vaccine.

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Figure 1: Neutralization breadth of anti-HIV monoclonal antibodies depends on antibody-generation technology and antigen configuration.


  1. Wu, X. et al. Science 329, 856–861 (2010).

    Article  CAS  Google Scholar 

  2. Zhou, T. et al. Science 329, 811–817 (2010).

    Article  CAS  Google Scholar 

  3. Scheid, J.F. et al. J. Immunol. Methods 343, 65–67 (2009).

    Article  CAS  Google Scholar 

  4. Kwong, P.D. & Wilson, I.A. Nat. Immunol. 10, 573–578 (2009).

    Article  CAS  Google Scholar 

  5. Hammond, P.W. mAbs 2, 157–164 (2010).

    Article  Google Scholar 

  6. Walker, L.M. et al. Science 326, 285–289 (2009).

    Article  CAS  Google Scholar 

  7. Pancera, M. et al. J. Virol. 84, 8098–8110 (2010).

    Article  CAS  Google Scholar 

  8. Bianchi, E. et al. Proc. Natl. Acad. Sci. USA 107, 10655–10660 (2010).

    Article  CAS  Google Scholar 

  9. Bommakanti, G. et al. Proc. Natl. Acad. Sci. USA. 107, 13701–13706 (2010).

    Article  CAS  Google Scholar 

  10. Rerks-Ngarm, S. et al. N. Engl. J. Med. 361, 2209–2220 (2009).

    Article  CAS  Google Scholar 

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Correspondence to Joseph G Joyce.

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J.G.J. and J.t.M. are employees of Merck & Co.

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Joyce, J., ter Meulen, J. Pushing the envelope on HIV-1 neutralization. Nat Biotechnol 28, 929–931 (2010).

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