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Towards patient-based cancer therapeutics

Orienting cancer drug discovery to the patient requires relating the genetic features of tumors to acquired gene and pathway dependencies and identifying small-molecule therapeutics that target them.

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Figure 1: The NCI's Cancer Target Discovery and Development (CTD2) Network aims to relate the genetic features of cancers to acquired cancer dependencies and to identify small molecules that target the dependencies.
Figure 2: Conceptual image of a matrix of data relating cancer genotype, cancer phenotype and sensitivity to highly specific small-molecule modulators of cancer-relevant proteins.

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Correspondence to Stuart L Schreiber.

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The Cancer Target Discovery and Development Network., Schreiber, S., Shamji, A. et al. Towards patient-based cancer therapeutics. Nat Biotechnol 28, 904–906 (2010). https://doi.org/10.1038/nbt0910-904

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