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Towards patient-based cancer therapeutics

Nature Biotechnology volume 28, pages904–906(2010)Cite this article

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Orienting cancer drug discovery to the patient requires relating the genetic features of tumors to acquired gene and pathway dependencies and identifying small-molecule therapeutics that target them.

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Figure 1: The NCI's Cancer Target Discovery and Development (CTD2) Network aims to relate the genetic features of cancers to acquired cancer dependencies and to identify small molecules that target the dependencies.
Figure 2: Conceptual image of a matrix of data relating cancer genotype, cancer phenotype and sensitivity to highly specific small-molecule modulators of cancer-relevant proteins.

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Affiliations

  1. Stuart L. Schreiber, Alykhan F. Shamji, Paul A. Clemons, Cindy Hon, Angela N. Koehler, Benito Munoz, Michelle Palmer, Andrew M. Stern & Bridget K. Wagner are at the Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

    Stuart L Schreiber, Alykhan F Shamji, Paul A Clemons, Cindy Hon, Angela N Koehler, Benito Munoz, Michelle Palmer, Andrew M Stern & Bridget K Wagner

  2. Scott Powers, Scott W. Lowe, Xuecui Guo, Alex Krasnitz, Eric T. Sawey, Raffaella Sordella, Lincoln Stein & Lloyd C. Trotman are at Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

    Scott Powers, Scott W Lowe, Xuecui Guo, Alex Krasnitz, Eric T Sawey, Raffaella Sordella, Lincoln Stein & Lloyd C Trotman

  3. Andrea Califano, Riccardo Dalla-Favera, Adolfo Ferrando, Antonio Iavarone, Laura Pasqualucci, José Silva & Brent R. Stockwell are at Columbia University, New York, New York, USA.

    Andrea Califano, Riccardo Dalla-Favera, Adolfo Ferrando, Antonio Iavarone, Laura Pasqualucci, José Silva & Brent R Stockwell

  4. William C. Hahn, Lynda Chin, Ronald A. DePinho, Jesse S. Boehm, Shuba Gopal, Alan Huang, David E. Root & Barbara A. Weir are at the Dana-Farber Cancer Institute, Cambridge, Massachusetts, USA.

    William C Hahn, Lynda Chin, Ronald A DePinho, Jesse S Boehm, Shuba Gopal, Alan Huang, David E Root & Barbara A Weir

  5. Daniela S. Gerhard & Jean Claude Zenklusen are at the US National Cancer Institute, Bethesda, Maryland, USA.

    Daniela S Gerhard & Jean Claude Zenklusen

  6. Michael G. Roth, Michael A. White, John D. Minna, John B. MacMillan & Bruce A. Posner are at the University of Texas, Southwestern Medical Center, Dallas, Texas, USA.

    Michael G Roth, Michael A White, John D Minna, John B MacMillan & Bruce A Posner

Authors
  1. Stuart L Schreiber
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  2. Alykhan F Shamji
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  4. Cindy Hon
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  5. Angela N Koehler
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  6. Benito Munoz
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  7. Michelle Palmer
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  8. Andrew M Stern
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  10. Scott Powers
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  18. Andrea Califano
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  19. Riccardo Dalla-Favera
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  23. José Silva
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  24. Brent R Stockwell
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  25. William C Hahn
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  28. Jesse S Boehm
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  30. Alan Huang
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  31. David E Root
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  35. Michael G Roth
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  36. Michael A White
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  37. John D Minna
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  38. John B MacMillan
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  39. Bruce A Posner
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Consortia

The Cancer Target Discovery and Development Network

Corresponding author

Correspondence to Stuart L Schreiber.

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The authors declare no competing financial interests.

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The Cancer Target Discovery and Development Network., Schreiber, S., Shamji, A. et al. Towards patient-based cancer therapeutics. Nat Biotechnol 28, 904–906 (2010). https://doi.org/10.1038/nbt0910-904

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