Orienting cancer drug discovery to the patient requires relating the genetic features of tumors to acquired gene and pathway dependencies and identifying small-molecule therapeutics that target them.
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Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types
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The Cancer Target Discovery and Development Network., Schreiber, S., Shamji, A. et al. Towards patient-based cancer therapeutics. Nat Biotechnol 28, 904–906 (2010). https://doi.org/10.1038/nbt0910-904
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DOI: https://doi.org/10.1038/nbt0910-904
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