Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Silencing prostate cancer

Systemic delivery of an siRNA–aptamer chimera leads to prostate cancer regression in mice.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Strategies for systemic delivery of siRNA.


  1. Whitehead, K.A., Langer, R. & Anderson, D.G. Nat. Rev. Drug Discov. 8, 129–138 (2009).

    Article  CAS  Google Scholar 

  2. Dassie, J.P. et al. Nat Biotechnol. 27, 839–846 (2009).

    Article  CAS  Google Scholar 

  3. McNamara, J.O. et al. Nat. Biotechnol. 24, 1005–1015 (2006).

    Article  CAS  Google Scholar 

  4. Zimmermann, T.S. et al. Nature 441, 111–114 (2006).

    Article  CAS  Google Scholar 

  5. Akinc, A. et al. Nat. Biotechnol. 26, 561–569 (2008).

    Article  CAS  Google Scholar 

  6. Frank-Kamenetsky, M. et al. Proc. Natl. Acad. Sci. USA 105, 11915–11920 (2008).

    Article  CAS  Google Scholar 

  7. Judge, A.D. et al. J. Clin. Invest. 119, 661–673 (2009).

    Article  CAS  Google Scholar 

  8. Peer, D. et al. Science 319, 627–630 (2008).

    Article  CAS  Google Scholar 

  9. Rozema, D.B. et al. Proc. Natl. Acad. Sci. USA 104, 12982–12987 (2007).

    Article  CAS  Google Scholar 

  10. Hu-Lieskovan, S. et al. Cancer Res 65, 8984–8992 (2005).

    Article  CAS  Google Scholar 

  11. Soutschek, J. et al. Nature 432, 173–178 (2004).

    Article  CAS  Google Scholar 

  12. Chu, T.C., Twu, K.Y., Ellington, A.D. & Levy, M. Nucleic Acids Res. 34, e73 (2006).

    Article  Google Scholar 

  13. Zhou, J. et al. Mol. Ther. 16, 1481–1489 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Antonin de Fougerolles.

Ethics declarations

Competing interests

A.D.F. and I.T. are employees of Alnylam Pharmaceuticals, a company engaged in the development of RNAi therapeutics.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Toudjarska, I., de Fougerolles, A. Silencing prostate cancer. Nat Biotechnol 27, 821–823 (2009).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing