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Upping the ante on antibodies

The current generation of antibodies has done more than make a few companies rich. It has laid the groundwork for ambitious companies to move to maturity.

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Figure 1: Anatomy of an optimized antibody.
Figure 2: By fusing the minimal binding domains of two antibodies that recognize either the immune cell or the target cell, a small bispecific antibody (green and red) is created that can now physically link immune cells and pathogenic cells.
Figure 3: DataMonitor assessed antibody companies in terms of maturity, from technology providers to fully integrated drug companies.


  1. 1

    Evans, D. & Das, R. Monoclonal Antibodies: Evolving into a $30 Billion Market (DataMonitor, London, UK, 2005).

    Google Scholar 

  2. 2

    Mitchell, P. Next generation monoclonals less profitable than trailblazers? Nat. Biotechnol. 23, 906 (2005).

    CAS  Article  Google Scholar 

  3. 3

    Presta, L. Antibody engineering for therapeutics. Curr. Opin. Struct. Biol. 13, 519–526 (2003).

    CAS  Article  Google Scholar 

  4. 4

    Lu, D. Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody. J. Biol. Chem. 279, 2856–2865 (2004).

    CAS  Article  Google Scholar 

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Baker, M. Upping the ante on antibodies. Nat Biotechnol 23, 1065–1072 (2005).

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