Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Upping the ante on antibodies

The current generation of antibodies has done more than make a few companies rich. It has laid the groundwork for ambitious companies to move to maturity.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Anatomy of an optimized antibody.
Figure 2: By fusing the minimal binding domains of two antibodies that recognize either the immune cell or the target cell, a small bispecific antibody (green and red) is created that can now physically link immune cells and pathogenic cells.
Figure 3: DataMonitor assessed antibody companies in terms of maturity, from technology providers to fully integrated drug companies.

References

  1. 1

    Evans, D. & Das, R. Monoclonal Antibodies: Evolving into a $30 Billion Market (DataMonitor, London, UK, 2005).

    Google Scholar 

  2. 2

    Mitchell, P. Next generation monoclonals less profitable than trailblazers? Nat. Biotechnol. 23, 906 (2005).

    CAS  Article  Google Scholar 

  3. 3

    Presta, L. Antibody engineering for therapeutics. Curr. Opin. Struct. Biol. 13, 519–526 (2003).

    CAS  Article  Google Scholar 

  4. 4

    Lu, D. Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody. J. Biol. Chem. 279, 2856–2865 (2004).

    CAS  Article  Google Scholar 

Download references

Author information

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Baker, M. Upping the ante on antibodies. Nat Biotechnol 23, 1065–1072 (2005). https://doi.org/10.1038/nbt0905-1065

Download citation

Further reading

Search

Quick links