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Arraying autoimmunity treatment

Nature Biotechnology volume 21, pages 1017–1019 (2003)Cite this article

Protein and peptide arrays that reveal antigens which induce a diverse autoantibody response can be used to guide tolerizing therapy.

Protein arrays offer great promise for profiling changes in protein levels and composition to develop new biomarkers for early diagnosis of disease and to design new treatments. But can the mass of data collected in such experiments be applied to practical, clinical use? In an exciting advance, Robinson et al.1 report in this issue the use of protein microarrays to predict and design a multicomponent protective DNA vaccine against an autoimmune disease. By revealing the spectrum of antibodies raised in individual mice during an autoimmune disease, microarray analysis is exploited to predict the relevant autoantigen cDNAs for inclusion in DNA vaccines. The authors demonstrate that superior protection is afforded by vaccines which raise the largest diversity of antibodies.

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Figure 1: Presentation of linear peptides by professional antigen presenting cells.

©Bob Crimi

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  1. the Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, 92121, California, USA

    Eli E Sercarz

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  1. Eli E Sercarz
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Sercarz, E. Arraying autoimmunity treatment. Nat Biotechnol 21, 1017–1019 (2003). https://doi.org/10.1038/nbt0903-1017

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