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Controlled Release of Interleukin-2 from Biodegradable Microspheres

Bio/Technology volume 8, pages 755–758 (1990)Cite this article

Abstract

We have evaluated the use of biodegradable poly(DL-lactide-co-glycolide) microspheres for the controlled release of interleukin-2 (IL-2) and its modified forms: succinyl IL-2 (SIL-2) and polyethylene glycol-modified IL-2 (PEG IL-2). We show that a microsphere formulation can be prepared from PEG IL-2 using HSA as an excipient which, after an initial burst, releases 2–3% PEG IL-2 per day in a bioactive form continuously over a 20- to 30-day period.

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Authors and Affiliations

  1. Cetus Corporation, 1400 Fifty-Third Street, Emeryville, CA, 94608

    Maninder Singh Hora, Rajsharan K. Rana, Jack H. Nunberg & Thomas R. Tice

  2. Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL, 35205

    Richard M. Gilley & Michael E. Hudson

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  1. Maninder Singh Hora
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  2. Rajsharan K. Rana
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  3. Jack H. Nunberg
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  4. Thomas R. Tice
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  5. Richard M. Gilley
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  6. Michael E. Hudson
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Hora, M., Rana, R., Nunberg, J. et al. Controlled Release of Interleukin-2 from Biodegradable Microspheres. Nat Biotechnol 8, 755–758 (1990). https://doi.org/10.1038/nbt0890-755

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