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Can HIV be cured with stem cell therapy?

Nature Biotechnology volume 28, pages 807–810 (2010)Cite this article

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Transplantation of human hematopoietic stem cells engineered to lack the viral coreceptor CCR5 confers resistance to HIV infection in mice.

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Figure 1: Reconstitution of an HIV-resistant lymphoid and myeloid system in an experimental model.

References

  1. Holt, N. et al. Nat. Biotechnol. 28, 839–847 (2010).

    Article  CAS  Google Scholar 

  2. Siliciano, J.D. et al. Nat. Med. 9, 727–728 (2003).

    Article  CAS  Google Scholar 

  3. Kuller, L.H. et al. PLoS Med. 5, e203 (2008).

    Article  Google Scholar 

  4. Phillips, A.N., Neaton, J. & Lundgren, J.D. AIDS 22, 2409–2418 (2008).

    Article  Google Scholar 

  5. Friedman, A.D., Triezenberg, S.J. & McKnight, S.L. Nature 335, 452–454 (1988).

    Article  CAS  Google Scholar 

  6. Baltimore, D. Nature 335, 395–396 (1988).

    Article  CAS  Google Scholar 

  7. Rossi, J.J., June, C.H. & Kohn, D.B. Nat. Biotechnol. 25, 1444–1454 (2007).

    Article  CAS  Google Scholar 

  8. McCune, J.M. Nature 410, 974–979 (2001).

    Article  CAS  Google Scholar 

  9. McCune, J.M. Cell 82, 183–188 (1995).

    Article  CAS  Google Scholar 

  10. Hutter, G. et al. N. Engl. J. Med. 360, 692–698 (2009).

    Article  Google Scholar 

  11. Moore, J.P., Kitchen, S.G., Pugach, P. & Zack, J.A. AIDS Res. Hum. Retroviruses 20, 111–126 (2004).

    Article  CAS  Google Scholar 

  12. Glass, W.G. et al. J. Exp. Med. 203, 35–40 (2006).

    Article  CAS  Google Scholar 

  13. DiGiusto, D.L. et al. Sci. Transl. Med. 2, 36ra43 (2010).

    Article  Google Scholar 

  14. Shimizu, S. et al. Blood 115, 1534–1544 (2010).

    Article  CAS  Google Scholar 

  15. Perez, E.E. et al. Nat. Biotechnol. 26, 808–816 (2008). w

    Article  CAS  Google Scholar 

  16. Hunt, P.W. et al. J. Infect. Dis. 194, 926–930 (2006).

    Article  CAS  Google Scholar 

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Acknowledgements

The authors wish to acknowledge amfAR, Project Inform, TAG and the AIDS Policy Project for supporting and stimulating cross-disciplinary discussion on the issues outlined in this commentary. The authors' work that contributed to this review was supported by the National Institute of Allergy and Infectious Diseases (RO1 AI087145 and K24AI069994 to S.G.D. and R37 AI40312 and DPI OD00329 to J.M.M.), the University of California, San Francisco (UCSF) Center for AIDS Research (P30 MH59037), the UCSF Clinical and Translational Science Institute (UL1 RR024131), the Harvey V. Berneking Living Trust and amfAR. J.M.M. is a recipient of the National Institutes of Health (NIH) Director's Pioneer Award Program, part of the NIH Roadmap for Medical Research.

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Authors and Affiliations

  1. Steven G. Deeks and Joseph M. McCune are in the Department of Medicine, University of California, San Francisco, California, USA.,

    Steven G Deeks & Joseph M McCune

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  1. Steven G Deeks
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Correspondence to Steven G Deeks or Joseph M McCune.

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Competing interests

S.G.D. has provided advice to Sangamo for the development of a phase 1/2 clinical study aimed at defining the role of CCR5 gene-modified mature T cells in HIV disease, and is currently participating without compensation on a DMSB for an ongoing investigator-initiated study at the University of Pennsylvania in which this technology is being explored.

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Deeks, S., McCune, J. Can HIV be cured with stem cell therapy?. Nat Biotechnol 28, 807–810 (2010). https://doi.org/10.1038/nbt0810-807

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