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Cancer biomarkers: a systems approach

The value of a diagnostic test should be assessed in the overall context of disease management.

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Figure 1
Figure 2: Cost per case detected for diseases of varying prevalence, considering screening tests with equal specificity and varying sensitivity (90% and 95%).

References

  1. 1

    Thompson, I.M. et al. J. Am. Med. Assoc. 294, 66–70 (2005).

    CAS  Article  Google Scholar 

  2. 2

    Etzioni, R. et al. Nat. Rev. Cancer 3, 243–252 (2003).

    CAS  Article  Google Scholar 

  3. 3

    Elmore, J.G. et al. N. Engl. J. Med. 338, 1089–1096 (1998).

    CAS  Article  Google Scholar 

  4. 4

    Ford, D. et al. Am. J. Hum. Genet. 62, 676–689 (1998).

    CAS  Article  Google Scholar 

  5. 5

    Madeline, M.M. et al. J. Infect. Dis. 186, 1565–1574 (2002).

    Article  Google Scholar 

  6. 6

    Hulka, B.S. Cancer screening. Degrees of proof and practical application. Cancer 62 Suppl. 8 1776–1780 (1988).

    CAS  Article  Google Scholar 

  7. 7

    Surveillance, Epidemiology, and End Results (SEER) Program, SEER*Stat Database: National Cancer Institute, DCCPS. Surveillance Research Program, Cancer Statistics Branch. <http://seer.cancer.gov/faststats/sites.php?site=Ovary%20Cancer&statrg=Prevalence>

  8. 8

    Kim, J.J., Wright, T.C. & Goldie, S.J. J. Am. Med. Assoc. 287, 2382–2390 (2002).

    Article  Google Scholar 

  9. 9

    Kelloff, G.J. et al. Clin. Cancer Res. 11, 7967–7985 (2005).

    CAS  Article  Google Scholar 

  10. 10

    Mankoff, D.A. & Krohn, K.A. in Drug Resistance in Cancer. (ed. Teicher, B.) 105–122 (Humana Press, Totowa, NJ, 2006).

    Book  Google Scholar 

  11. 11

    Linden, H.M. et al. J. Clin. Oncol. 24, 2793–2799 (2006).

    CAS  Article  Google Scholar 

  12. 12

    Mortimer, J.E. et al. J. Clin. Oncol. 19, 2797–2803 (2001).

    CAS  Article  Google Scholar 

  13. 13

    Dehdashti, F. et al. Int. J. Radiat. Oncol. Biol. Phys. 55, 1233–1238 (2003).

    Article  Google Scholar 

  14. 14

    Rajendran, J.G. & Krohn, K.A. in Positron Emission Tomography: Principles and Practice. (eds. Bailey, D.L., Townsend, D.W., Valk, P.E. & Maisey, M.N.) 689–696 (Springer Verlag, London, 2002).

    Google Scholar 

  15. 15

    Hendrikse, N.H. et al. Cancer Res. 59, 2411–2416 (1999).

    CAS  PubMed  Google Scholar 

  16. 16

    Sasongko, L. et al. Clin. Pharmacol. Ther. 77, 503–514 (2005).

    CAS  Article  Google Scholar 

  17. 17

    Belinsky, S.A. et al. Cancer Res. 66, 3338–3344 (2006).

    CAS  Article  Google Scholar 

  18. 18

    Lynch, T.J. et al. N. Engl. J. Med. 350, 2129–2139 (2004).

    CAS  Article  Google Scholar 

  19. 19

    Weber, W.A. J. Nucl. Med. 46, 983–995 (2005).

    CAS  PubMed  Google Scholar 

  20. 20

    Stroobants, S. et al. Eur. J. Cancer 39, 2012–2020 (2003).

    CAS  Article  Google Scholar 

  21. 21

    Mankoff, D.A., Shields, A.F. & Krohn, K.A. Radiol. Clin. North Am. 43, 153–167 (2005).

    Article  Google Scholar 

  22. 22

    Theilmann, R.J. et al. Neoplasia 6, 831–837 (2004).

    Article  Google Scholar 

  23. 23

    Blankenberg, F., Ohtsuki, K. & Strauss, H.W. Q. J. Nucl. Med. 43, 170–176 (1999).

    CAS  PubMed  Google Scholar 

  24. 24

    Yagle, K.J. et al. J. Nucl. Med. 46, 658–666 (2005).

    CAS  PubMed  Google Scholar 

  25. 25

    Bonadonna, G. et al. N. Engl. J. Med. 294, 405–410 (1976).

    CAS  Article  Google Scholar 

  26. 26

    Robbins, R.J. et al. J. Clin. Endocrinol. Metab. 91, 498–505 (2006).

    CAS  Article  Google Scholar 

  27. 27

    Quaranta, V., Weaver, A.M., Cummings, P.T. & Anderson, A.R. Clin. Chim. Acta 24, 173–179 (2005).

    Article  Google Scholar 

  28. 28

    Loeve, F. et al. J. Natl. Cancer Inst. 92, 557–563 (2000).

    CAS  Article  Google Scholar 

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Hartwell, L., Mankoff, D., Paulovich, A. et al. Cancer biomarkers: a systems approach. Nat Biotechnol 24, 905–908 (2006). https://doi.org/10.1038/nbt0806-905

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