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Cancer biomarkers: a systems approach

Nature Biotechnology volume 24, pages 905–908 (2006)Cite this article

The value of a diagnostic test should be assessed in the overall context of disease management.

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Figure 1
Figure 2: Cost per case detected for diseases of varying prevalence, considering screening tests with equal specificity and varying sensitivity (90% and 95%).

References

  1. Thompson, I.M. et al. J. Am. Med. Assoc. 294, 66–70 (2005).

    Article  CAS  Google Scholar 

  2. Etzioni, R. et al. Nat. Rev. Cancer 3, 243–252 (2003).

    Article  CAS  Google Scholar 

  3. Elmore, J.G. et al. N. Engl. J. Med. 338, 1089–1096 (1998).

    Article  CAS  Google Scholar 

  4. Ford, D. et al. Am. J. Hum. Genet. 62, 676–689 (1998).

    Article  CAS  Google Scholar 

  5. Madeline, M.M. et al. J. Infect. Dis. 186, 1565–1574 (2002).

    Article  Google Scholar 

  6. Hulka, B.S. Cancer screening. Degrees of proof and practical application. Cancer 62 Suppl. 8 1776–1780 (1988).

    Article  CAS  Google Scholar 

  7. Surveillance, Epidemiology, and End Results (SEER) Program, SEER*Stat Database: National Cancer Institute, DCCPS. Surveillance Research Program, Cancer Statistics Branch. <http://seer.cancer.gov/faststats/sites.php?site=Ovary%20Cancer&statrg=Prevalence>

  8. Kim, J.J., Wright, T.C. & Goldie, S.J. J. Am. Med. Assoc. 287, 2382–2390 (2002).

    Article  Google Scholar 

  9. Kelloff, G.J. et al. Clin. Cancer Res. 11, 7967–7985 (2005).

    Article  CAS  Google Scholar 

  10. Mankoff, D.A. & Krohn, K.A. in Drug Resistance in Cancer. (ed. Teicher, B.) 105–122 (Humana Press, Totowa, NJ, 2006).

    Book  Google Scholar 

  11. Linden, H.M. et al. J. Clin. Oncol. 24, 2793–2799 (2006).

    Article  CAS  Google Scholar 

  12. Mortimer, J.E. et al. J. Clin. Oncol. 19, 2797–2803 (2001).

    Article  CAS  Google Scholar 

  13. Dehdashti, F. et al. Int. J. Radiat. Oncol. Biol. Phys. 55, 1233–1238 (2003).

    Article  Google Scholar 

  14. Rajendran, J.G. & Krohn, K.A. in Positron Emission Tomography: Principles and Practice. (eds. Bailey, D.L., Townsend, D.W., Valk, P.E. & Maisey, M.N.) 689–696 (Springer Verlag, London, 2002).

    Google Scholar 

  15. Hendrikse, N.H. et al. Cancer Res. 59, 2411–2416 (1999).

    CAS  PubMed  Google Scholar 

  16. Sasongko, L. et al. Clin. Pharmacol. Ther. 77, 503–514 (2005).

    Article  CAS  Google Scholar 

  17. Belinsky, S.A. et al. Cancer Res. 66, 3338–3344 (2006).

    Article  CAS  Google Scholar 

  18. Lynch, T.J. et al. N. Engl. J. Med. 350, 2129–2139 (2004).

    Article  CAS  Google Scholar 

  19. Weber, W.A. J. Nucl. Med. 46, 983–995 (2005).

    CAS  PubMed  Google Scholar 

  20. Stroobants, S. et al. Eur. J. Cancer 39, 2012–2020 (2003).

    Article  CAS  Google Scholar 

  21. Mankoff, D.A., Shields, A.F. & Krohn, K.A. Radiol. Clin. North Am. 43, 153–167 (2005).

    Article  Google Scholar 

  22. Theilmann, R.J. et al. Neoplasia 6, 831–837 (2004).

    Article  Google Scholar 

  23. Blankenberg, F., Ohtsuki, K. & Strauss, H.W. Q. J. Nucl. Med. 43, 170–176 (1999).

    CAS  PubMed  Google Scholar 

  24. Yagle, K.J. et al. J. Nucl. Med. 46, 658–666 (2005).

    CAS  PubMed  Google Scholar 

  25. Bonadonna, G. et al. N. Engl. J. Med. 294, 405–410 (1976).

    Article  CAS  Google Scholar 

  26. Robbins, R.J. et al. J. Clin. Endocrinol. Metab. 91, 498–505 (2006).

    Article  CAS  Google Scholar 

  27. Quaranta, V., Weaver, A.M., Cummings, P.T. & Anderson, A.R. Clin. Chim. Acta 24, 173–179 (2005).

    Article  Google Scholar 

  28. Loeve, F. et al. J. Natl. Cancer Inst. 92, 557–563 (2000).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Genetics,

    Lee Hartwell, David Mankoff & Elizabeth Swisher

  2. Division of Nuclear Medicine,

    Lee Hartwell, David Mankoff & Elizabeth Swisher

  3. Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific, Box 356460, Seattle, 98195, Washington, USA

    Lee Hartwell, David Mankoff & Elizabeth Swisher

  4. Public Health Sciences Division,

    Lee Hartwell, Amanda Paulovich & Scott Ramsey

  5. Clinical Research Division at the Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, 98109, Washington, USA

    Lee Hartwell, Amanda Paulovich & Scott Ramsey

  6. Institute for Systems Biology, 1441 North 34th Street, Seattle, 98103-8904, Washington, USA

    Scott Ramsey

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Hartwell, L., Mankoff, D., Paulovich, A. et al. Cancer biomarkers: a systems approach. Nat Biotechnol 24, 905–908 (2006). https://doi.org/10.1038/nbt0806-905

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