Therapeutic monoclonal antibodies against the pro-inflammatory cytokine TNF-α have been successfully used to treat chronic inflammatory diseases. In this issue, Mouritsen and colleagues (p. 666) take this approach one step further by developing a method to immunize against self TNF-α. Mice immunized with modified TNF-α stimulated a booster-dependent T-cell dependent anti-TNF-α response—relieving symptoms of cachexia and arthritis.
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DeWitt, N. Anti-inflammatory antibodies. Nat Biotechnol 17, 626 (1999). https://doi.org/10.1038/10825
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DOI: https://doi.org/10.1038/10825