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When blind is better: Protein design by evolution

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  1. Dawkins, R. 1986. The blind watchmaker. Longmans, London.

    Google Scholar 

  2. Dennett, D. C. 1995. Darwin's dangerous ideal. Evolution and the meanings of life. Simon & Schuster, New York.

    Google Scholar 

  3. Buchholz, F. Anagrand, P.-O., and Stewart, A. F. 1998. Nature Biotechnology. 16: 657–662.

    Article  CAS  Google Scholar 

  4. Kumamaru, T. et al. 1998. Nature Biotechnolgy 16: 663–656.

    Article  CAS  Google Scholar 

  5. Tawfik, D.S. and Griffiths, A.D. 1998. Nature Biotechnology 16: 652–656.

    Article  CAS  Google Scholar 

  6. Dahiyat, B.I. and Mayo, S.L. 1997. Science 278: 82–87.

    Article  CAS  Google Scholar 

  7. Fujii, I. et al. 1998 Nature Biotechnology 16: 463–472.

    Article  CAS  Google Scholar 

  8. Crameri, A., Raillard, S.-A., Stemmer, W.P.C. 1998. Nature 391: 288–291.

    Article  CAS  Google Scholar 

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Arnold, F. When blind is better: Protein design by evolution. Nat Biotechnol 16, 617–618 (1998).

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