Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Paring down signaling complexity

Nature Biotechnology volume 28, pages 681–682 (2010)Cite this article

Subjects

A new method for characterizing signaling responses to pairs of agonists predicts how cells react to higher-order combinations of external stimuli.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Combining pairwise agonist scanning (PAS) with neural-network modeling to capture a complex stimulus landscape.

References

  1. Miller-Jensen, K., Janes, K.A., Brugge, J.S. & Lauffenburger, D.A. Nature 448, 604–608 (2007).

    Article  CAS  Google Scholar 

  2. Chatterjee, M.S., Purvis, J.E., Brass, L.F. & Diamond, S.L. Nat. Biotechnol. 28, 727–732 (2010).

    Article  CAS  Google Scholar 

  3. Gaudet, S. et al. Mol. Cell. Proteomics 4, 1569–1590 (2005).

    Article  CAS  Google Scholar 

  4. Janes, K.A. et al. Science 310, 1646–1653 (2005).

    Article  CAS  Google Scholar 

  5. Natarajan, M. et al. Nat. Cell Biol. 8, 571–580 (2006).

    Article  CAS  Google Scholar 

  6. Geva-Zatorsky, N. et al. Cell 140, 643–651 (2010).

    Article  CAS  Google Scholar 

  7. Hsueh, R.C. et al. Sci. Signal. 2, ra22 (2009).

    Article  Google Scholar 

  8. Albeck, J.G. et al. Nat. Rev. Mol. Cell Biol. 7, 803–812 (2006).

    Article  CAS  Google Scholar 

  9. Krogh, A. Nat. Biotechnol. 26, 195–197 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kevin A. Janes is in the Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.,

    Kevin A Janes

Authors
  1. Kevin A Janes
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kevin A Janes.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Janes, K. Paring down signaling complexity. Nat Biotechnol 28, 681–682 (2010). https://doi.org/10.1038/nbt0710-681

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0710-681

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing