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Biomarker validation by targeted mass spectrometry

Nature Biotechnology volume 27, pages 622–623 (2009)Cite this article

A multilaboratory study demonstrates the potential for establishing quantitative targeted proteomic assays for moderately to highly abundant plasma proteins.

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Figure 1: The relationship between tandem mass spectrometry (MS/MS) and multiple-reaction monitoring (MRM).

References

  1. Adonna, T. et al. Nat. Biotechnol. 27, 633–641 (2009).

    Article  Google Scholar 

  2. Bell, A.W. et al. Nat. Methods 6, 423–430 (2009).

    Article  CAS  Google Scholar 

  3. Palmer, C. et al. PLoS ONE 3, e2633 (2008). http://www.plosone.org/doi/pone.0002633

    Article  Google Scholar 

  4. Crump, C. et al. Cancer Epidemiol. Biomarkers Prev. 9, 1107–1111 (2000).

    CAS  PubMed  Google Scholar 

  5. Brown, P. & Palmer, C. PLoS Med. (in the press).

  6. Faca, V. et al. J. Proteome Res. 6, 3558–3565 (2007).

    Article  CAS  Google Scholar 

  7. Whiteaker, J.R. et al. J. Proteome Res. 6, 828–836 (2007).

    Article  CAS  Google Scholar 

  8. Schröder, F.H. et al. New Engl. J. Med. 360, 1320–1328 (2009).

    Article  Google Scholar 

  9. Andriole, G.L. et al. New Engl. J. Med. 360, 1310–1319 (2009).

    Article  CAS  Google Scholar 

  10. Pollack, A. New York Times A15 (1 June 2009). http://www.nytimes.com/2009/06/01/health/research/01cancer.html?_r=2&ref=health

    Google Scholar 

  11. Pollak, M.N. & Foulkes, W.D. Nat. Rev. Cancer 3, 297–303 (2003).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Martin McIntosh and Matthew Fitzgibbon are in the Computational Biology and Molecular Diagnostics Programs at the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.,

    Martin McIntosh & Matthew Fitzgibbon

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  1. Martin McIntosh
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  2. Matthew Fitzgibbon
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Correspondence to Martin McIntosh.

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McIntosh, M., Fitzgibbon, M. Biomarker validation by targeted mass spectrometry. Nat Biotechnol 27, 622–623 (2009). https://doi.org/10.1038/nbt0709-622

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