Metabolic reconfiguration precedes transcriptional regulation in the antioxidant response

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Timing the metabolic reconfiguration of the antioxidant response.


  1. 1

    Chechik, G. et al. Nat. Biotechnol. 26, 1251–1259 (2008).

    CAS  Article  Google Scholar 

  2. 2

    Pollak, N., Dolle, C. & Ziegler, M. Biochem. J. 402, 205–218 (2007).

    CAS  Article  Google Scholar 

  3. 3

    Ralser, M. et al. J. Biol. 6, 10 (2007).

    Article  Google Scholar 

  4. 4

    Daran-Lapujade, P. et al. Proc. Natl. Acad. Sci. USA 104, 15753–15758 (2007).

    CAS  Article  Google Scholar 

  5. 5

    Shenton, D. & Grant, C.M. Biochem. J. 374, 513–519 (2003).

    CAS  Article  Google Scholar 

  6. 6

    Janero, D.R., Hreniuk, D. & Sharif, H.M. Am. J. Physiol. 266, C179–C188 (1994).

    CAS  Article  Google Scholar 

  7. 7

    Ito, Y., Pagano, P.J., Tornheim, K., Brecher, P. & Cohen, R.A. Am. J. Physiol. 270, H81–H87 (1996).

    CAS  PubMed  Google Scholar 

  8. 8

    Grant, C.M., Quinn, K.A. & Dawes, I.W. Mol. Cell. Biol. 19, 2650–2656 (1999).

    CAS  Article  Google Scholar 

  9. 9

    Colussi, C. et al. FASEB J. 14, 2266–2276 (2000).

    CAS  Article  Google Scholar 

  10. 10

    Wamelink, M.M., Struys, E.A. & Jakobs, C. J. Inherit. Metab. Dis. 31, 703–717 (2008).

    CAS  Article  Google Scholar 

Download references


We are grateful to B. Timmermann and S. Krobitsch (MPI-MG) for providing materials and to M. Gibson (University of Pittsburgh Medical Center) for critical reading of the manuscript. Part of this work was funded by the Max Planck Society.

Author information



Supplementary information

Supplementary Text and Figures

Supplementary Figures 1–3 and Supplementary Methods (PDF 585 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ralser, M., Wamelink, M., Latkolik, S. et al. Metabolic reconfiguration precedes transcriptional regulation in the antioxidant response. Nat Biotechnol 27, 604–605 (2009).

Download citation

Further reading